ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation of numerous spike mutations. To understand the Omicron antigenic shift, we determined cryo-electron microscopy and x-ray crystal structures of the spike protein and the receptor-binding domain bound to the broadly neutralizing sarbecovirus monoclonal antibody (mAb) S309 (the parent mAb of sotrovimab) and to the human ACE2 receptor. We provide a blueprint for understanding the marked reduction of binding of other therapeutic mAbs that leads to dampened neutralizing activity. Remodeling of interactions between the Omicron receptor-binding domain and human ACE2 likely explains the enhanced affinity for the host receptor relative to the ancestral virus.
ABSTRACT
This paper presents a mobile application prototype that pretends to identify the state of languishing in postgraduate students, who have been dealing with social distancing due COVID-19 pandemic. In order to make visible the social significance of tools that encourage students and other users to understand their emotions and to look for a good mental health accompanied by specialists, with the knowledge that no one is spare of suffering from an emotional problem. In addition, the data obtained may be used to take appropriate measures by the corresponding authorities by the hand of mental health specialized. The presented prototype development process in this paper responds to an interface design based on human-computer interaction methods and tools and shows some suggested improvements after the evaluating phase. © 2021, Springer Nature Switzerland AG.
ABSTRACT
The declaration of the coronavirus strain (SARS-CoV-2) as a pandemic by theWorld Health Organization (WHO) forces the confinement of millions of people, as well as to modify habits and lifestyles. Mexico is a country with high numbers of diseases that are associated with physical inactivity and sedentary lifestyle, which cause thousands of deaths a year.The aim is to compare the level of physical activity and the time dedicated to sedentary behaviors before and during confinement due to COVID-19 in a sample of Mexican adults.The population under study is 1,027 subjects (59.9% women and 47.1% men) with a median age of 22 and an average of 27.36 years of age, the majority are Latino, students, single, with completed undergraduate studies and average socioeconomic level.The results showed that the level of physical activity tends to decrease due to confinement on the seven days of the week and the time allocated to sedentary behaviors such as watching TV / video / DVD's / Netflix, resting, doing cognitive activities (hobbies), play computer / video games (not active), listen to music, and chat with family or friends increases. It confirms that COVID-19 lockdown has a negative impact on people's lifestyles during free time. Innovative actions are required to mitigate the negative consequences of home confinement. © 2021 Federacion Espanola de Docentes de Educacion Fisica. All rights reserved.